Chemotaxis Inhibitory Protein of Staphylococcus aureus (CHIPS)
CHIPS was identified by Karen Ellen Veltkamp and Carla de Haas in 2004. CHIPS binds two chemoattractant receptors, the receptor for complement C5a (C5aR1 or CD88) and the receptor for formylated peptides (FPR1). Binding to the receptors blocks ligand (C5a and fMLF respectively) induced activation including migration.
FTFEPFPTNEEIESNKKMLEKEKAYKESFKNSGLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY
References:
1) Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent.