CpvlPanton-Valentine leukocidin (PVL)

In 2013 Andras Spaan identified the leukocyte receptor for PVL, the human C5aR. Leukocyte subset specific toxicity of the bi-component PVL (LukF-PV and LukS-PV) was already known for years, but its receptor counterpart was not described. The two C5a receptors, C5aR (CD88) and C5L2 (C5aR2) proved to guide the leukocyte subset specificity as well as species specificity (whereby the murine counterpart is non-permissive).

 

DNNIENIGDGAEVVKRTEDTSSDKWGVTQNIQFDFVKDKKYNKDALILKMQGFINSKTTYYNYKNTDHIKAMRWPFQYNIGLKTNDPNVDLINYLPKNKIDSVNVSQTLGYNIGGNFNSGPSTGGNGSFNYSKTISYNQQNYISEVERQNSKSVQWGIKANSFITSLGKMSGHDPNLFVGYKPYSQNPRDYFVPDNELPPLVHSGFNPSFIATVSHEKGSGDTSEFEITYGRNMDVTHATRRTTHYGNSYLEGSRIHNAFVNRNYTVKYEVNWKTHEIKVKGHN

 

References:

1) The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors.

2) Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors.

3) Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?