SCIN

Staphylococcal Complement Inhibitor (SCIN)

SCIN was identified by Suzan Rooijakkers in 2005. SCIN is a blocker of all three complement pathways, but most efficiently blocks the alternative pathway. SCIN blocks C3 convertases and also stabilizes and dimerizes these convertases. SCIN has two homologues called SCIN-B and SCIN-C.

 

STSLPTSNEYQNEKLANELKSLLDELNVNELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKSKY

 

References:

1) Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.

2) Staphylococcal complement evasion by various convertase-blocking molecules.