Thesis Rob van Dalen (2019) – Bacterial Infections and Immunity

Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular
pattern that triggers pro-inflammatory cytokine responses through langerin (CD207) on skin Langerhans cells.
A common genetic variation in langerin (CD207) compromises internalization of Staphylococcus aureus.
Synthetic wall teichoic acid provides new insights into the systemic and
mucosal human antibody repertoire for Staphylococcus aureus glycotypes.
The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid.