Gamma-hemolysin component C (HlgC)

In 2014 Andras Spaan identified the chemokine receptors CXCR1, CXCR2 and CCR2 as the targets for the Gamma-haemolisin AB and the C5aR and C5L2 for Gamma-haemolysin CB. In addition, for HlgAB a CCR2 dependent contribution was shown in a mice S.aureus bacteremia model. Structure is top view of the octameric γ-hemolysin, a bicomponent pore-forming toxin composed of LukF and Hlg2 (reference #2).





1) The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors.

2) Crystal structure of the octameric pore of staphylococcal γ-hemolysin reveals the β-barrel pore formation mechanism by two components.