Staphylococcal Peroxidase INhibitor (SPIN)
SPIN was identified by Nienke de Jong in 2017 from a secretome phage-display library with neutrophil granule proteins as target. SPIN is an inhibitor of myeloperoxidase (MPO), an enzym present in the azurophylic granules of neutrophils involved in bacterial killing through hypochlorous acid generation.
1) Immune evasion by a staphylococcal inhibitor of myeloperoxidase.
2) A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).