Stapylococcal Superantigen-Like 3 (SSL3)
SSL3 binds to the extracellular domain of TLR2 and thereby inhibits cell activation with specific TLR1/2 or TLR6/2 ligands as described by Bart Bardoel in 2012. The crystal structure of SSL3 and its complex with TLR2 was resolved by Kirsten Koymans in 2015 revealing that SSL3 covers the entrance to the lipopeptide binding pocket on TLR2 thereby preventing activation and dimerization with TLR6.
Note: truncated sequence comprising residues 134–326
1) Evasion of Toll-like receptor 2 activation by staphylococcal superantigen-like protein 3.
2) Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3.