Staphylococcus aureus is a bacterium that causes harmless infections in most people. However, some previously healthy people suffer from life-threatening infections with this bacterium. Physicians and scientists don’t understand the huge variability between humans in the severity of their infection. Wet will investigate whether inborn, genetic defects in the immunity of these previously healthy but severely ill people explain their susceptibility to life-threatening infections with S. aureus. Like a compass and using human genetics as a tool,we will hopefully contribute to the identification of new therapeutic leads for prevention and treatment of staphylococcal infections.