Selected publications

Kuipers A, Stapels DA, Weerwind LT, Ko YP, Ruyken M, Lee JC, van Kessel KP, Rooijakkers SH. “The S. aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis.”  Microbiology 2016 Apr 25. doi: 10.1099/mic.0.000293 (http://www.ncbi.nlm.nih.gov/pubmed/27112346)

Stapels DA, Kuipers A, von Köckritz-Blickwede M, Ruyken M, Tromp AT, Horsburgh MJ, de Haas CJ, van Strijp JA, van Kessel KP, Rooijakkers SH. “Staphylococcus aureus protects its immune-evasion proteins against degradation by neutrophil serine proteases.” Cellular Microbiology 2016 Apr;18(4):536-45, DOI: 10.1111/cmi.12528 (http://www.ncbi.nlm.nih.gov/pubmed/26418545)

Berends ET, Gorham RD Jr, Ruyken M, Soppe JA, Orhan H, Aerts PC, de Haas CJ, Gros P, Rooijakkers SH. “Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes”. BMC Biology 2015 Nov 9;13:93 (http://www.ncbi.nlm.nih.gov/pubmed/26552476)

Berends ET, Mohan S, Miellet WR, Ruyken M, Rooijakkers SH. “Contribution of the complement Membrane Attack Complex to the bactericidal activity of human serum.” Molecular Immunology 2015 Jun;65(2):328-35. (http://www.ncbi.nlm.nih.gov/pubmed/25725315)

Stapels DA, Geisbrecht BV, Rooijakkers SH. “Neutrophil serine proteases in antibacterial defense”. Current Opinion in Microbiology. 2014 Nov 18;23:42-48. (http://www.ncbi.nlm.nih.gov/pubmed/25461571)

Woehl JL, Stapels DA, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SH, Geisbrecht BV. “The Extracellular Adherence Protein from the C3 Proconvertase.”Journal of Immunology. 2014 Dec 15;193(12):6161-71. (http://www.ncbi.nlm.nih.gov/pubmed/25381436)

Stapels DA, Ramyar KX, Bischoff M, von Köckritz-Blickwede M, Milder FJ, Ruyken M, Eisenbeis J, McWhorter WJ, Herrmann M, van Kessel KP, Geisbrecht BV, Rooijakkers SH. “Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors”.Proc Natl Acad Sci USA. 2014 Sep 9;111(36):13187-92. (http://www.ncbi.nlm.nih.gov/pubmed/25161283)

Berends ET, Kuipers A, Ravesloot M, Urbanus RT and Rooijakkers SH. ”Bacteria under stress by complement ant coagulation” FEMS Microbiology Reviews. 2014;38(6):1146-71. (http://www.ncbi.nlm.nih.gov/pubmed/2506546)

van Strijp JA, Rooijakkers SH. Entrapment exploited. Trends Microbiology. 2014;22(2):55-7. (http://www.ncbi.nlm.nih.gov/pubmed/24387831)

Ko YP, Kuipers A, Freitag CM, Jongerius I, Medina E, van Rooijen WJ, Spaan AN, van Kessel KP, Höök M, Rooijakkers SH. Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface. PLoS Pathogens. 2013 Dec;9(12):e1003816. (http://www.ncbi.nlm.nih.gov/pubmed/24348255)

Berends ET, Dekkers JF, Nijland R, Kuipers A, Soppe JA, van Strijp JA, Rooijakkers SH. Distinct localization of the complement C5b-9 complex on Gram-positive bacteria. Cell Microbiol. 2013;15(12):1955-68. (http://www.ncbi.nlm.nih.gov/pubmed/23869880)

Rooijakkers SH#, Geiss-Liebisch S# , Beczala A, Sanchez-Carballo P, Kruszynska K, Repp C, Sakinc T, Vinogradov E, Holst O, Huebner J, Theilacker C. “Secondary Cell Wall Polymers of Enterococcus faecalis Are Critical for Resistance to Complement Activation via Mannose-binding Lectin”.Journal of Biological Chemistry. 2012 Nov 2;287(45):37769-77. #Equal contribution (http://www.ncbi.nlm.nih.gov/pubmed/2290821)

Laarman AJ, Mijnheer G, Mootz JM, van Rooijen WJ, Ruyken M, Malone CL, Heezius EC, Ward R, Milligan G, van Strijp JA, de Haas CJ, Horswill AR, van Kessel KP, Rooijakkers SH. “Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis”.EMBO Journal. 2012 Aug 29;31(17):3607-19. (http://www.ncbi.nlm.nih.gov/pubmed/22850671)

Jongerius I, von Köckritz-Blickwede M, Horsburgh MJ, Ruyken M, Nizet V, Rooijakkers SH.”Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses”.Journal of Innate Immunity. 2012;4(3):301-11. (http://www.ncbi.nlm.nih.gov/pubmed/22327617)

Laarman AJ, Bardoel BW, Ruyken M, Fernie J, Milder FJ, van Strijp JA, Rooijakkers SH. “Pseudomonas aeruginosa alkaline protease blocks complement activation via the classical and lectin pathways”.Journal of Immunology. 2012 Jan 1;188(1):386-93. (http://www.ncbi.nlm.nih.gov/pubmed/22131330)

Laarman AJ, Ruyken M, Malone CL, van Strijp JA, Horswill AR, Rooijakkers SH.“Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.” Journal of Immunology. 2011 Jun 1;186(11):6445-53. (http://www.ncbi.nlm.nih.gov/pubmed/21502375)

Rooijakkers SH, Rasmussen SL, McGillivray SM, Bartnikas TB, Mason AB, Friedlander AM, Nizet V. “Human transferrin confers serum resistance against Bacillus anthracis.”Journal of Biological Chemistry. 2010 Sep 3;285(36):27609-13. (http://www.ncbi.nlm.nih.gov/pubmed/20615872)

Jongerius I, Garcia BL, Geisbrecht BV, van Strijp JA, Rooijakkers, SH. “Convertase inhibitory properties of the staphylococcal extracellular complement binding protein.” Journal of Biological Chemistry. 2010 Mar 19. (http://www.ncbi.nlm.nih.gov/pubmed/20304920)

Jongerius I, Puister M, Wu J, Ruyken M, van Strijp JA and Rooijakkers SH. “Staphylococcal complement inhibitor modulates phagocyte responses by dimerization of convertases.” Journal of Immunology. 2010 Jan 184: 420-425 (http://www.ncbi.nlm.nih.gov/pubmed/19949103)

Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P. “Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.” Nature Immunology. 2009 Jul;10(7):721-7. (http://www.ncbi.nlm.nih.gov/pubmed/19503103)

Jongerius I, Köhl J, Pandey MK, Ruyken M, Van Kessel KPM, Van Strijp JAG and Rooijakkers SH. “Staphylococcal complement evasion by various convertase-blocking molecules”.Journal of Experimental Medicine, 2007 Oct 1;204(10):2461-71. (http://www.ncbi.nlm.nih.gov/pubmed/17893203)

Rooijakkers SH, Van Kessel KPM, Van Strijp JAG. “Staphylococcal Innate Immune evasion”. Trends in Microbiology, 2005, Dec 13(12): 596-601. (http://www.ncbi.nlm.nih.gov/pubmed/16242332)

Rooijakkers SH, Ruyken M, Roos A, Daha MR, Presanis J, Sim R, Van Wamel WJB, Van Kessel KP, Van Strijp JAG. “Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases”. Nature Immunology, 2005, Sep 6(9): 920-927. (http://www.ncbi.nlm.nih.gov/pubmed/16086019)