Extracellular Fibrinogen Binding Protein (Efb)
Efb was first described in 1994, refered to as fib, and is a secreted fibrinogen binding protein but does not participate in bacterial adhesion. Fibrinogen binding activity is located within the N-terminal half of Efb. In addition, the C-terminal part binds Complement C3d. Using truncated and mutated variants Ya-Ping Ko and Annemarie Kuipers showed that combining these two ligand binding sites, Efb is an unique phagocyte escape protein.
1) Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.
2) Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb).
3) Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence.