Staphylococcal Complement Inhibitor (SCIN)
SCIN was identified by Suzan Rooijakkers in 2005. SCIN is a blocker of all three complement pathways, but most efficiently blocks the alternative pathway. SCIN blocks C3 convertases and also stabilizes and dimerizes these convertases. SCIN has two homologues called SCIN-B and SCIN-C.
1) Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
2) Staphylococcal complement evasion by various convertase-blocking molecules.